From Latin laxus, lax is a adjective which refers to something relaxed, free or that does not have the tension that, by nature, should have . The term can be used in reference to something physical or symbolic.
For example: “I like the laxiest fabrics, which don't stick so much to the body”, "He was always a man of lax beliefs, capable of contradicting himself with great naturalness", “A loose tablecloth that does not fit the table is the best decorative option for the banquet”, "You can't be lax in compliance with the rules".
It is known as loose connective tissue to the type of tissue of the organism that presents a low percentage of fibers and whose origin is in the tissue mesechymal Loose connective tissue can be divided into mucous connective tissue or reticular connective tissue , among other subtypes.
In a symbolic sense, the lax is associated with the vagueness , the Print or what undefined . If a person claims that he has a "Lax relationship" With your partner, you will be indicating that the degree of commitment is not very strong. Similarly, a president who provides a "Lax support" to a minister, he will be giving an endorsement that can be considered as not very firm or lends itself to misunderstandings and misrepresentations.
He lax complexion on the other hand it is a disease infrequent that involves the degeneration of the elastic fibers of the skin. It is caused by a defect in the enzyme lysyl oxidase which makes the skin loose and seems to hang from the body .
Most cases of lax complexion are inherited in an autosomal recessive, dominant, or recessive manner linked to the X chromosome, although there are reports of acquired cases. Given the histological abnormalities in the structure or in the amount of elastin that occurs in almost all cases of lax complexion, research studies have focused on genetic mutations that lead to alterations in elastin processing in the extracellular matrix or structure.
Autosomal dominant complexion (ADCL)
ADCL symptoms may appear at any point in the developing of a person between his birth and the beginning of his adulthood. In some cases, only the symptom of lax skin can be seen. However, certain families see defects in the eyes and nose, as well as lung (pulmonary emphysema) and vascular (aortic aneurysm) problems. It is advisable to perform pulmonary function tests and echocardiography to prevent the aforementioned disorders, as they can put the patient's life at risk.
Autosomal recessive lax complexion (ARCL)
ARCL is found in various subtypes, depending on the symptoms of each case and the gene that causes the disease; basically, three types can be recognized, and the first two are also divided into more than one subtype. Let's look at the main characteristics of some of them:
ARCL1A
* loose skin, problems pulmonary such as emphysema (during the first years of life) and hernias;
* the age at which these symptoms appear varies greatly, even within a family;
* It is due to mutations in the FBLN5 gene.
ARCL2A
* wrinkled skin throughout the body (usually, age makes this better);
* congenital dislocation of the hip, myopia, hernias and elongated anterior fontanel;
* many cases have a significant delay in psychomotor development, as well as crisis of epilepsy;
* It is caused by mutations in the ATP6V0A2 gene.
ARCL3
* stunted and mental retardation (of varying intensity);
* cataracts, lax joints;
* appearance of excessive aging;
* the disorders Pulmonary and cardiovascular are not common.
